DESCRIPTION:

QTL associated with radiation induced gastroschisis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (72726204)

LABEL:

QTL-Rigs1-Mouse-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1330298

AUTHORS:

Hillebrandt S, Matern S, Lammert F

TITLE:

Mouse models for genetic dissection of polygenic gastrointestinal diseases.

JOURNAL:

European journal of clinical investigation Feb 2003, Vol 33, pp. 155-60

ABSTRACT:

Many diseases with a major public health impact are the result of complex interactions between environmental factors and multiple genes. In the past decade, methods for genome analysis, in particular quantitative trait locus (QTL) analysis in animal models, were developed to identify and localize the genes responsible for multifactorial (polygenic) diseases; QTL analysis is based on experimental crosses between inbred strains with high and low genetic susceptibility. Recently the genes underlying several QTLs could be cloned successfully. Here we describe the impact of these genomic approaches in mice on our understanding of the multifactorial genetics of three gastrointestinal diseases related to metabolism (cholesterol cholelithiasis), development (gastroschisis), and colorectal cancer. The examples demonstrate how mouse models continue to be an invaluable tool in unravelling complex pathomechanisms and unlocking our understanding of human diseases. PUBMED: 12588290
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