GeneSet Information

Tier II GS136574 • radiation-induced acute myeloid leukemia sensitivity 2 (Ramls2, Published QTL Chr 6)

DESCRIPTION:

QTL associated with radiation-induced acute myeloid leukemia sensitivity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (55149860)

LABEL:

QTL-Ramls2-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3722391

AUTHORS:

Boulton E, Cole C, Knight A, Cleary H, Snowden R, Plumb M

TITLE:

Low-penetrance genetic susceptibility and resistance loci implicated in the relative risk for radiation-induced acute myeloid leukemia in mice.

JOURNAL:

Blood Mar 2003, Vol 101, pp. 2349-54

ABSTRACT:

Inbred CBA/H mice are susceptible to radiation-induced acute myeloid leukemia (r-AML), and C57BL/6 mice are resistant. A genome-wide screen for linkage between genotype and phenotype (r-AML) of 67 affected (CBA/H x C57BL/6)F1 x CBA/H backcross mice has revealed at least 2 suggestive loci that contribute to the overall lifetime risk for r-AML. Neither is necessary or sufficient for r-AML, but relative risk is the net effect of susceptibility (distal chromosome 1) and resistance (chromosome 6) loci. An excess of chromosome 6 aberrations in mouse r-AML and bone marrow cells up to 6 months after irradiation in vivo suggests the locus confers a proliferative advantage during the leukemogenic process. The stem cell frequency regulator 1 (Scfr1) locus maps to distal chromosome 1 and determines the frequency of hemopoietic stem cells (HSCs) in inbred mice, suggesting that target size may be one factor in determining the relative susceptibility of inbred mice to r-AML. PUBMED: 12411293
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Annotation Information

No sequence read archive data associated with this GeneSet.


Chromosomes, Human, Pair 6 (D002896)
Bone Marrow Cells (D001854)
Bone Marrow (D001853)
Mice (D051379)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Genetic Predisposition to Disease (D020022)
Leukemia (D007938)
Risk (D012306)
Overall (D016424)
Leukemia, Myeloid, Acute (D015470)
Genotype (D005838)
Microscopy, Electron, Scanning Transmission (D017348)
Leukemia, Myeloid (D007951)
Cells (D002477)
Bone and Bones (D001842)
Stem Cells (D013234)
Maps (D019532)
bone (MA:0001459)
bone marrow (MA:0000134)
leukemia (MP:0002026)
cell (GO:0005623)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351