DESCRIPTION:

QTL associated with Plasmodium yoelli malaria resistance. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (103503469)

LABEL:

QTL-Pymr-Mouse-Chr 9

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3055094

AUTHORS:

Ohno T, Ishih A, Kohara Y, Yonekawa H, Terada M, Nishimura M

TITLE:

Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice.

JOURNAL:

Immunogenetics Dec 2001, Vol 53, pp. 736-40

ABSTRACT:

The disease outcome in malaria caused by the protozoan parasite Plasmodium is influenced by host genetic factors. To identify host genes conferring resistance to infection with the malaria parasite, we undertook chromosomal mapping using a whole-genome scanning approach in cross-bred mice. NC/Jic mice all died with high parasitemia within 8 days of infection with 1 x 10(5) parasitized erythrocytes. In contrast, 129/SvJ mice all completely excluded malaria parasites from the circulation and remained alive 21 days after infection. We performed linkage analysis in backcross [(NC/Jic x 129/SvJ)xNC/Jic] mice. The Pymr ( Plasmodium yoelii malaria resistance) locus was mapped to the telomeric portion of mouse Chromosome (Chr) 9. This locus controls host survival and parasitemia after infection. The Char1 locus ( P. chabaudi resistance locus 1), controlling host survival and peak parasitemia in P. chabaudi infection, was previously mapped to the same region. This host resistance locus mapping to Chr 9 may represent a ubiquitous locus controlling susceptibility to rodent malaria. Elucidation of the function of this gene will provide valuable insights into the mechanism of host defense against malaria parasite infection. PUBMED: 11862405
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