DESCRIPTION:

QTL associated with pristane induced arthritis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (96885628)

LABEL:

QTL-Prtia1-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3626077

AUTHORS:

Jensen JR, Peters LC, Borrego A, Ribeiro OG, Cabrera WH, Starobinas N, Siqueira M, Ibaez OC, De Franco M

TITLE:

Involvement of antibody production quantitative trait loci in the susceptibility to pristane-induced arthritis in the mouse.

JOURNAL:

Genes and immunity Jan 2006, Vol 7, pp. 44-50

ABSTRACT:

Mice obtained by bidirectional selective breeding for high (HIII) or low (LIII) antibody (Ab) production are resistant or extremely susceptible to pristane-induced arthritis (PIA), respectively. Several quantitative trait loci regulating Ab production (Ab QTL) have been mapped in these lines, which were used to investigate the influence of these Ab QTL in PIA. Parental HIII and LIII mice and their F1 and F2 intercrosses were injected twice with pristane, and arthritis was observed for 200 days. In LIII mice PIA was more severe and incidence was 100% at day 105, while F1 and F2 mice showed intermediate values. HIII mice were totally resistant. Microsatellite polymorphisms of Ab QTL were analysed and D3Mit100 alleles cosegregated significantly with PIA incidence, severity and onset in F2 intercross mice, while the other four markers showed suggestive values. Results indicate colocalization of QTL for Ab production and PIA susceptibility. Moreover, the different cytokine and IgG isotype profiles observed in HIII and LIII lines after PIA induction are useful to candidate genes endowed with the regulation of the Ab production and arthritis phenotypes. PUBMED: 16435023
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