DESCRIPTION:

QTL associated with prion incubation time 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (88709736)

LABEL:

QTL-Pitm2-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2151896

AUTHORS:

Manolakou K, Beaton J, McConnell I, Farquar C, Manson J, Hastie ND, Bruce M, Jackson IJ

TITLE:

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice.

JOURNAL:

Proceedings of the National Academy of Sciences of the United States of America Jun 2001, Vol 98, pp. 7402-7

ABSTRACT:

The incubation period (IP) and the neuropathology of transmissible spongiform encephalopathies (TSEs) have been extensively used to distinguish prion isolates (or strains) inoculated into panels of inbred mouse strains. Such studies have shown that the bovine spongiform encephalopathy (BSE) agent is indistinguishable from the agent causing variant Creutzfeldt-Jakob disease (vCJD), but differs from isolates of sporadic CJD, reinforcing the idea that the vCJD epidemic in Britain results from consumption of contaminated beef products. We present a mouse model for genetic and environmental factors that modify the incubation period of BSE cross-species transmission. We have used two mouse strains that carry the same prion protein (PrP) allele, but display a 100-day difference in their mean IP following intracerebral inoculation with primary BSE isolate. We report genetic effects on IP that map to four chromosomal regions, and in addition we find significant factors of host environment, namely the age of the host\'s mother, the age of the host at infection, and an X-cytoplasm interaction in the host. PUBMED: 11404459
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