DESCRIPTION:

QTL associated with prion incubation determinant 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37049651)

LABEL:

QTL-Pid2-Mouse-Chr 9

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1890506

AUTHORS:

Stephenson DA, Chiotti K, Ebeling C, Groth D, DeArmond SJ, Prusiner SB, Carlson GA

TITLE:

Quantitative trait loci affecting prion incubation time in mice.

JOURNAL:

Genomics Oct 2000, Vol 69, pp. 47-53

ABSTRACT:

Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility. PUBMED: 11013074
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