DESCRIPTION:

QTL associated with plasmacytoma susceptibility 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (52685214)

LABEL:

QTL-Pcyts6-Mouse-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2665067

AUTHORS:

Symons RC, Daly MJ, Fridlyand J, Speed TP, Cook WD, Gerondakis S, Harris AW, Foote SJ

TITLE:

Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.

JOURNAL:

Proceedings of the National Academy of Sciences of the United States of America Aug 2002, Vol 99, pp. 11299-304

ABSTRACT:

There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males were found to be more prone to plasmacytomagenesis. Different loci influence tumor susceptibility in male and female mice. Survival in females may be largely controlled by a pair of interacting loci on chromosomes 2 and 17. PUBMED: 12149518
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