DESCRIPTION:

QTL associated with pulmonary adenoma resistance 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (70388916)

LABEL:

QTL-Par2-Mouse-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1855887

AUTHORS:

Wang M, Wang Y, You M, Devereux TR

TITLE:

Analysis of the Par2 modifier of pulmonary adenoma formation in mice.

JOURNAL:

Experimental lung research Mar 2005, Vol 31, pp. 193-204

ABSTRACT:

Inbred strains of mouse show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QLTs) located on multiple chromosomes. A major lung tumor resistance QLT, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates. PUBMED: 15828125
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