DESCRIPTION:

QTL associated with platelet activation 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (60013817)

LABEL:

QTL-Pact1-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1100875

AUTHORS:

Ault KA, Knowles C, Mitchell J, Brown CL, Schultz KL, Beamer WG

TITLE:

Genetic control of platelet activation in inbred mouse strains.

JOURNAL:

Platelets None 1997, Vol 8, pp. 235-41

ABSTRACT:

Platelet activation in inbred mouse strains was studied using expression of P-selectin as a marker of activated platelets. P-selectin expression in response to no added stimulus (spontaneous activation) or in response to adenosine diphosphate (ADP) and epinephrine or thrombin, was assessed using a flow cytometric assay. Wide variation in the responsiveness of different strains was observed with strains SJL and AKR in particular showing very high levels of spontaneous activation. Genetic studies suggest that this phenomenon is under control of a small number of genes and that the same loci are probably responsible for the high activation of both SJL and AKR. Bone marrow transplant experiments show that the trait is expressed in the platelet itself. Screening of SWXJ and AKXD recombinant inbred lines suggests that one of the responsible genes is located on chromosome 3. PUBMED: 16793654
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