DESCRIPTION:

QTL associated with ovarian teratoma susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (96605945)

LABEL:

QTL-Ots1-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:109357

AUTHORS:

Lee GH, Bugni JM, Obata M, Nishimori H, Ogawa K, Drinkwater NR

TITLE:

Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes.

JOURNAL:

Cancer research Feb 1997, Vol 57, pp. 590-3

ABSTRACT:

The LT/Sv mouse strain is characterized by its abnormally high incidence of spontaneous ovarian teratomas. These tumors have been shown to originate from parthenogenetic oocytes, which are spontaneously induced to divide. Both spontaneous parthenogenesis and ovarian teratomas are extremely rare for other mouse strains, including C57BL/6J. To identify the genes responsible for this unique phenotype of female LT/Sv mice, we performed linkage analysis of female (C57BL/6J x LT/Sv)F2 mice. A locus on chromosome 6 designated Ots1 (ovarian teratoma susceptibility) was identified as the single major locus that increases the frequency of teratomas in a semidominant manner. PUBMED: 9044831
Find other GeneSets from this publication