DESCRIPTION:

QTL associated with ocular degeneration with sex reversal modifier 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (68060298)

LABEL:

QTL-Odsm1-Mouse-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2653281

AUTHORS:

Poirier C, Qin Y, Adams CP, Anaya Y, Singer JB, Hill AE, Lander ES, Nadeau JH, Bishop CE

TITLE:

A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice.

JOURNAL:

Genetics Nov 2004, Vol 168, pp. 1557-62

ABSTRACT:

The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods termed Odsm1(A). Here we show that phenotypic sex depends on a complex interaction between the suppressor and the transgene. Suppression can be achieved only if the transgene is transmitted paternally. In addition, the suppressor itself exhibits a maternal effect, suggesting that it may act on chromatin in the early embryo. PUBMED: 15579706
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