DESCRIPTION:

QTL associated with modifier of p53-deficiency 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35392252)

LABEL:

QTL-Mp53d1-Mouse-Chr 19

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3054216

AUTHORS:

Ochiai Y, Tamura Y, Saito Y, Matsuki A, Wakabayashi Y, Aizawa Y, Niwa O, Kominami R

TITLE:

Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice.

JOURNAL:

Oncogene Feb 2003, Vol 22, pp. 1098-102

ABSTRACT:

The strain dependency of the spectrum and latency of tumors has been reported in p53-deficient (KO) mice, suggesting the presence of modifiers for the outcome of the p53 deficiency. The modifiers provide clues to the oncogenic pathway in cells lacking p53, the most frequently mutated gene in a wide variety of human cancers. To search the modifiers, we induced 160 lymphomas and 69 skin tumors by gamma-irradiation of p53(KO/+) backcross mice between BALB/c and MSM strains and performed genome scan. BALB/c-derived alleles at three loci on chromosome 19, Mp53D1 (modifier of p53-deficiency) at D19Mit5, Mp53D2 at D19Mit90 and Mp53D3 at D19Mit123, extended the latency of thymic lymphoma development (P values in Mantel-Cox test were 0.0007, 0.0007 and 0.0003, respectively). Mp53D3 also increased the latency of skin tumors (P value, 0.0008). The linkage of Mp53D2 was confirmed by the experiment using 94 p53-KO mice consomic for chromosome 19, providing a significant linkage. However, the linkage was not confirmed for Mp53D1 or Mp53D3, suggesting epistasis of genes involved in the tumorigenesis. PUBMED: 12592396
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