DESCRIPTION:

QTL associated with modifier of Trp53 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (70313264)

LABEL:

QTL-Motp1-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3575566

AUTHORS:

Evans SC, Liang M, Amos C, Gu X, Lozano G

TITLE:

A novel genetic modifier of p53, mop1, results in embryonic lethality.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Jun 2004, Vol 15, pp. 415-23

ABSTRACT:

The heterogeneity that occurs in the tumor spectrum and latency in Li-Fraumeni syndrome (LFS) patients with inherited mutations in p53 suggest risk modifiers at loci other than the major gene. We developed a mouse model to investigate these risk modifiers. Inbred CE/J mice, which succumb to multiple types of tumors similar to those found in LFS, were crossed with the p53-null 129/Sv (129-Trp53(tm1Tyj)) mouse. In this cross, we uncovered evidence for a genetic modifier of p53, mop1, based on an unexpected mix of genotypes in the F2 progeny from Mendelian expectations. A model in which a recessive CE/J allele in combination with p53 heterozygosity or homozygosity results in lethality most closely fits the data. Using simple-sequence length polymorphism analysis of the entire genome, we identified a putative chromosomal region for this modifier of p53 on mouse chromosome 11 centromeric to p53. PUBMED: 15181534
Find other GeneSets from this publication