GeneSet Information

Tier II GS136271 • modifier of obesity 2 (Mobe2, Published QTL Chr 13)

DESCRIPTION:

QTL associated with modifier of obesity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (67271283)

LABEL:

QTL-Mobe2-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3037101

AUTHORS:

Stoehr JP, Byers JE, Clee SM, Lan H, Boronenkov IV, Schueler KL, Yandell BS, Attie AD

TITLE:

Identification of major quantitative trait loci controlling body weight variation in ob/ob mice.

JOURNAL:

Diabetes Jan 2004, Vol 53, pp. 245-9

ABSTRACT:

The adipocyte hormone leptin constitutes an important component of the regulation of energy homeostasis; leptin-deficient animals, such as obese mice, are strikingly overweight. The seemingly uninhibited weight gain in obese mice belies the fact that control of energy homeostasis remains under precise, heritably modifiable control. Herein, we report large, heritable differences in body weight and food intake between BTBR-ob/ob and B6-ob/ob mice. We have identified two loci, called modifier of obese (Moo1 and Moo2), that explain the majority of the heritable variance in (BTBR x B6) F(2)-ob/ob mice. Using interval-specific congenic mouse lines, we mapped Moo1 to an 8-Mb segment of chromosome 2 and demonstrated that Moo1 exerts its effects primarily by regulating total fat mass. Although null alleles of leptin are rare, the majority of overweight adults are leptin resistant, suggesting that leptin-independent pathways, such as those studied here, are important regulators of energy homeostasis. Thus, the identification of these loci may provide important new insights into the pathogenesis of human obesity. PUBMED: 14693723
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Annotation Information

No sequence read archive data associated with this GeneSet.


Eating (D004435)
Social Control, Formal (D012926)
Homeostasis (D006706)
Weight Gain (D015430)
Alleles (D000483)
Animals (D000818)
Humans (D006801)
Mice (D051379)
Chromosomes (D002875)
Research Report (D058028)
Quantitative Trait Loci (D040641)
Mice, Obese (D008820)
Adult (D000328)
Adipocytes (D017667)
Chromosomes, Human, Pair 2 (D002889)
Food (D005502)
Obesity (D009765)
Identification (Psychology) (D007062)
Hormones (D006728)
Leptin (D020738)
Body Weight (D001835)
Overweight (D050177)
adipose tissue (MA:0000009)
obese (MP:0001261)
pathogenesis (GO:0009405)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351