DESCRIPTION:

QTL associated with learning contextual 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (79090292)

LABEL:

QTL-Lrnx3-Mouse-Chr 9

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2148270

AUTHORS:

Owen EH, Christensen SC, Paylor R, Wehner JM

TITLE:

Identification of quantitative trait loci involved in contextual and auditory-cued fear conditioning in BXD recombinant inbred strains.

JOURNAL:

Behavioral neuroscience Apr 1997, Vol 111, pp. 292-300

ABSTRACT:

Fear conditioning shows associations formed between contextual or auditory stimuli with an unconditioned stimulus. Inbred mouse strains differ in their ability to demonstrate fear conditioning, suggesting at least a partial genetic influence. The present study identified the possible chromosomal loci regulating fear conditioning in BXD recombinant inbred strains using quantitative trait loci (QTL) analysis. Estimates of heritability for all 3 measures of conditioning were about .28. Correlational analyses between genetic markers and strain means identified multiple putative QTLs. The strongest associations were on Chromosomes 1 and 17 for freezing to the context, Chromosome 12 for freezing to an altered context, and Chromosome 1 for freezing to the auditory stimulus. Overlapping QTLs may indicate some common genes that underlie aspects of this learning task. PUBMED: 9106670
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