DESCRIPTION:

QTL associated with longevity extending gene 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (119108059)

LABEL:

QTL-Leg2-Mouse-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1890584

AUTHORS:

Klebanov S, Astle CM, Roderick TH, Flurkey K, Archer JR, Chen J, Harrison DE

TITLE:

Maximum life spans in mice are extended by wild strain alleles.

JOURNAL:

Experimental biology and medicine (Maywood, N.J.) Oct 2001, Vol 226, pp. 854-9

ABSTRACT:

The genes that control basic aging mechanisms in mammals are unknown. By using two four-way crosses, each including a strain derived from wild, undomesticated stocks, we identified two quantitative trait loci that extend murine life spans by approximately 10%. In one cross, the longest-lived 18% of carriers of the D8Mit171 marker allele from the MOLD/Rk strain, Mus m. molossinus, outlived the longest lived 18% of noncarriers by 129 days (P = 5.4 x 10(-5)); in a second cross, carriers of the D10Mit267 allele from the CAST/Ei strain, Mus m. castaneus, outlived noncarriers by 125 days ( P = 1.6 x 10(-6)). In both crosses, P < 1.0 x 10(-4 )is considered significant. Because these life span increases required that all essential biological systems function longer than normal, these alleles most likely retarded basic aging mechanisms in multiple biological systems simultaneously. PUBMED: 11568309
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