DESCRIPTION:

QTL associated with inspiratory timing at baseline QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (51563737)

LABEL:

QTL-Itbq1-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1328329

AUTHORS:

Tankersley CG, DiSilvestre DA, Jedlicka AE, Wilkins HM, Zhang L

TITLE:

Differential inspiratory timing is genetically linked to mouse chromosome 3.

JOURNAL:

Journal of applied physiology (Bethesda, Md. : 1985) Jul 1998, Vol 85, pp. 360-5

ABSTRACT:

Genetic control of differential inspiratory timing (TI) at baseline has been previously demonstrated among inbred mouse strains. The inheritance pattern for TI between C3H/HeJ (C3; 188 +/- 3 ms) and C57BL/6J (B6; 111 +/- 2 ms) progenitors was consistent with a two-gene model. By using the strain distribution pattern for recombinant inbred strains derived from C3 and B6 progenitors, 100% concordance was established between TI phenotypes and DNA markers on mouse chromosome 3. This genotype-phenotype hypothesis was tested by typing 52 B6C3F2 (F2) progeny by using simple sequence repeat DNA markers (n = 21) polymorphic between C3 and B6 strains on mouse chromosome 3. Linkage analysis compared marker genotypes to baseline ventilatory phenotypes by computing log-likelihood values. A putative quantitative trait locus located in proximity to D3Mit119 was significantly associated with baseline TI phenotypes. At the peak (log-likelihood = 3.3), the putative quantitative trait locus determined 25% of the phenotypic variance in TI among F2 progeny. In conclusion, this genetic model of ventilatory characteristics demonstrated an important linkage between differential baseline TI and a candidate genomic region on mouse chromosome 3. PUBMED: 9655796
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