GeneSet Information

Tier II GS136048 • insulin dependent diabetes susceptibility 4 (Idd4, Published QTL Chr 11)

DESCRIPTION:

QTL associated with insulin dependent diabetes susceptibility 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (74677336)

LABEL:

QTL-Idd4-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:96406

AUTHORS:

Takenaka K, Prasolava TK, Wang JC, Mortin-Toth SM, Khalouei S, Gan OI, Dick JE, Danska JS

TITLE:

Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells.

JOURNAL:

Nature immunology Dec 2007, Vol 8, pp. 1313-23

ABSTRACT:

Graft failure in the transplantation of hematopoietic stem cells occurs despite donor-host genetic identity of human leukocyte antigens, suggesting that additional factors modulate engraftment. With the nobese diabetic (NOD)-severe combined immunodeficiency (SCID) xenotransplantation model, we found that the NOD background allowed better hematopoietic engraftment than did other strains with equivalent immunodeficiency-related mutations. We used positional genetics to characterize the molecular basis for this strain specificity and found that the NOD Sirpa allele conferred support for human hematopoiesis. NOD SIRP-alpha showed enhanced binding to the human CD47 ligand, and its expression on mouse macrophages was required for support of human hematopoiesis. Thus, we have identified Sirpa polymorphism as a potent genetic determinant of the engraftment of human hematopoietic stem cells. PUBMED: 17982459
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Annotation Information

No sequence read archive data associated with this GeneSet.


Alleles (D000483)
Humans (D006801)
Genetics (D005823)
Mice (D051379)
Antigens (D000941)
Leukocytes (D007962)
Transplants (D019737)
Insulin (D007328)
Polymorphism, Genetic (D011110)
Transplantation, Heterologous (D014183)
Transplantation (D014180)
Microscopy, Electron, Scanning Transmission (D017348)
Cells (D002477)
HLA Antigens (D006680)
Stem Cells (D013234)
Pedigree (D010375)
Macrophages (D008264)
Mutation (D009154)
Hematopoietic Stem Cells (D006412)
Hematopoiesis (D006410)
binding (GO:0005488)
hemopoiesis (GO:0030097)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351