GeneSet Information

Tier II GS136047 • insulin dependent diabetes susceptibility 3 (Idd3, Published QTL Chr 3)

DESCRIPTION:

QTL associated with insulin dependent diabetes susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (60270627)

LABEL:

QTL-Idd3-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-10-22

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:96405

AUTHORS:

Moritoki Y, Tsuda M, Tsuneyama K, Zhang W, Yoshida K, Lian ZX, Yang GX, Ridgway WM, Wicker LS, Ansari AA, Gershwin ME

TITLE:

B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.

JOURNAL:

Cellular immunology None 2011, Vol 268, pp. 16-23

ABSTRACT:

There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are not a component of PBC and not found in the other murine models. To address the immunopathology in these mice, we generated genetically B cell deficient Igμ(-/-) NOD.c3c4 mice and compared the immunopathology of these animals to control B cell sufficient NOD.c3c4 mice. B cell deficient mice demonstrated decreased number of non-B cells in the liver accompanied by reduced numbers of activated natural killer cells. The degree of granuloma formation and bile duct damage were comparable to NOD.c3c4 mice. In contrast, liver inflammation, biliary cyst formation and salivary gland inflammation was significantly attenuated in these B cell deficient mice. In conclusion, B cells play a critical role in promoting liver inflammation and also contribute to cyst formation as well as salivary gland pathology in autoimmune NOD.c3c4 mice, illustrating a critical role of B cells in modulating specific organ pathology and, in particular, in exacerbating both the biliary disease and the sialadenitis. PUBMED: 21349500
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Annotation Information

No sequence read archive data associated with this GeneSet.


Granuloma (D006099)
Animals (D000818)
Bile Ducts (D001652)
Humans (D006801)
Play and Playthings (D010988)
Mice (D051379)
Pathology (D010336)
Role (D012380)
Liver (D008099)
Insulin (D007328)
Killer Cells, Natural (D007694)
Inflammation (D007249)
Cells (D002477)
Cholangitis (D002761)
Cysts (D003560)
Organizations (D009938)
Bile (D001646)
Antibodies (D000906)
B-Lymphocytes (D001402)
Sialadenitis (D012793)
Salivary Glands (D012469)
bile (MA:0002513)
bile duct (MA:0000354)
liver (MA:0000358)
salivary gland (MA:0000346)
bile duct inflammation (MP:0003254)
salivary gland inflammation (MP:0001870)
biliary cyst (MP:0003266)
liver inflammation (MP:0001860)
abnormal inflammatory response (MP:0001845)
cell (GO:0005623)
biosynthetic process (GO:0009058)
granuloma formation (GO:0002432)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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