GeneSet Information

Tier II GS136013 • heart rate quantitative locus 3 (Hrq3, Published QTL Chr 1)


QTL associated with heart rate quantitative locus 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (92584545)


QTL-Hrq3-Mouse-Chr 1









Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B


QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice.


Physiological genomics Jul 2002, Vol 10, pp. 5-12


To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantitative locus 6) on chromosome 15 (Chr 15; peak, 16 cM; 95% confidence interval, 0-25 cM) and Bpq7 on Chr 7 (peak, 42 cM; 95% confidence interval, 35-50 cM) that were significantly associated with blood pressure. We also identified two loci, Hrq1 (heart rate quantitative locus 1) and Hrq2, on D2Mit304 (peak, 72 cM; 95% confidence interval 60-80 cM) and D15Mit184 (peak, 25 cM; 95% confidence interval 20-35 cM), respectively, that were significantly associated with heart rate. A significant gene-gene interaction for heart rate was found between Hrq1 and D1Mit10 (peak, 57 cM; 95% confidence interval, 45-75 cM); the latter QTL was named Hrq3. We identified a significant locus for heart weight, Hwq1 (heart weight quantitative locus 1), at D14Mit67 (peak, 38 cM; 95% confidence interval, 20-43 cM). Identification of the genes for these QTL should lead to a better understanding of the causes of essential hypertension. PUBMED: 12118100
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Annotation Information

Pressure (D011312)
Chromosomes (D002875)
Comprehension (D032882)
Heart Rate (D006339)
Quantitative Trait Loci (D040641)
Chromosomes, Human, Pair 15 (D002884)
Hypertension (D006973)
Blood Pressure (D001794)
Identification (Psychology) (D007062)
Confidence Intervals (D016001)
hypertension (MP:0000231)
chromosome (GO:0005694)

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