GeneSet Information

Tier II GS135931 • horizontal distance traveled (Hdis, Published QTL Chr 1)

DESCRIPTION:

QTL associated with horizontal distance traveled. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (90464815)

LABEL:

QTL-Hdis-Mouse-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Willis-Owen SA, Flint J

TITLE:

The genetic basis of emotional behaviour in mice.

JOURNAL:

European journal of human genetics : EJHG Jun 2006, Vol 14, pp. 721-8

ABSTRACT:

The last decade has witnessed a steady expansion in the number of quantitative trait loci (QTL) mapped for complex phenotypes. However, despite this proliferation, the number of successfully cloned QTL has remained surprisingly low, and to a great extent limited to large effect loci. In this review, we follow the progress of one complex trait locus; a low magnitude moderator of murine emotionality identified some 10 years ago in a simple two-strain intercross, and successively resolved using a variety of crosses and fear-related phenotypes. These experiments have revealed a complex underlying genetic architecture, whereby genetic effects fractionate into several separable QTL with some evidence of phenotype specificity. Ultimately, we describe a method of assessing gene candidacy, and show that given sufficient access to genetic diversity and recombination, progression from QTL to gene can be achieved even for low magnitude genetic effects. PUBMED: 16721408
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Annotation Information



Genetic Variation (D014644)
Quantitative Trait Loci (D040641)
Recombination, Genetic (D011995)
Architecture as Topic (D001108)
Health Services Accessibility (D006297)

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