DESCRIPTION:

QTL associated with hepatocarcinogenesis susceptibility 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (81821259)

LABEL:

QTL-Hcs1-Mouse-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-10-22

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:96056

AUTHORS:

Gariboldi M, Manenti G, Canzian F, Falvella FS, Pierotti MA, Della Porta G, Binelli G, Dragani TA

TITLE:

Chromosome mapping of murine susceptibility loci to liver carcinogenesis.

JOURNAL:

Cancer research Jan 1993, Vol 53, pp. 209-11

ABSTRACT:

The validity of mouse liver tumors is controversial in the risk assessment of carcinogenicity of chemicals in humans, because mice used in carcinogenicity bioassays are genetically predisposed to liver tumors. The argument could be resolved once liver tumor susceptibility genes have been cloned and their role in liver tumor development elucidated. We performed a genetic linkage analysis to map murine liver tumor susceptibility genes, as a first step toward their identification. An F2 population of 87 urethane-treated male A/J x C3H/He mice was scored with 83 genetic markers. Three regions, localized on chromosomes 7, 8, and 12, were found to contain putative liver tumor susceptibility genes. PUBMED: 8417808
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