GeneSet Information

Tier II GS135917 • graft-versus-host disease 2 (Gvhd2, Published QTL Chr 4)

DESCRIPTION:

QTL associated with graft-versus-host disease 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (150944103)

LABEL:

QTL-Gvhd2-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1346067

AUTHORS:

Allen RD, Dobkins JA, Harper JM, Slayback DL

TITLE:

Genetics of graft-versus-host disease, I. A locus on chromosome 1 influences development of acute graft-versus-host disease in a major histocompatibility complex mismatched murine model.

JOURNAL:

Immunology Feb 1999, Vol 96, pp. 254-61

ABSTRACT:

Graft-versus-host disease (GVHD) is the major complication occurring after bone marrow transplantation. The severity of GVHD varies widely, with this variation generally being attributed to variation in the degree of disparity between host and donor for minor histocompatibility antigens. However, it is also possible that other forms of polymorphism, such as polymorphisms in immune effector molecules, might play a significant role in determining GVHD severity. In order to investigate this hypothesis, we are studying the genetic factors that influence GVHD development in a murine model. We here report the first results of this analysis, which demonstrate that a locus on Chromosome 1 of the mouse, and possibly also a locus on Chromosome 4, exert considerable influence over the development of one aspect of acute GVHD - splenomegaly - in a parent-->F1 murine model. These results demonstrate that non-MHC genes can exert quite significant effects on the development of GVHD-associated pathology and that gene mapping can be used as a tool to identify these loci. Further analysis of such loci will allow identification of the mechanism whereby they influence GVHD and may lead in the future to improved selection of donors for human bone marrow transplantation. PUBMED: 10233703
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Annotation Information

No sequence read archive data associated with this GeneSet.


Minor Histocompatibility Antigens (D015778)
Chromosomes, Human, Pair 4 (D002894)
Bone Marrow (D001853)
Forecasting (D005544)
Major Histocompatibility Complex (D008285)
Humans (D006801)
Play and Playthings (D010988)
Minors (D033242)
Splenomegaly (D013163)
Genetics (D005823)
Mice (D051379)
Tissue Donors (D014019)
Chromosome Mapping (D002874)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Research Report (D058028)
Histocompatibility Antigens (D006649)
Histocompatibility (D006648)
Antigens (D000941)
Bone Marrow Transplantation (D016026)
Pathology (D010336)
Graft vs Host Disease (D006086)
Role (D012380)
Polymorphism, Genetic (D011110)
Transplantation (D014180)
Lead (D007854)
Bone and Bones (D001842)
Identification (Psychology) (D007062)
bone (MA:0001459)
bone marrow (MA:0000134)
enlarged spleen (MP:0000691)
host (GO:0018995)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351