DESCRIPTION:

QTL associated with granular brain lesions. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (65754442)

LABEL:

QTL-Gbrln-Mouse-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3047352

AUTHORS:

Krass KL, Colinayo V, Ghazalpour A, Vinters HV, Lusis AJ, Drake TA

TITLE:

Genetic loci contributing to age-related hippocampal lesions in mice.

JOURNAL:

Neurobiology of disease Jul 2003, Vol 13, pp. 102-8

ABSTRACT:

C57BL/6J mice develop genetically determined age-related hippocampal granular deposits that have some similarities to lesions seen in the brains of human patients with tau protein related neurodegenerative disorders ("tauopathies"). We sought to identify the genetic loci responsible for these in an F2 intercross of inbred mouse strains C57BL/6J and DBA/2J, using quantitative trait locus (QTL) analysis. Hippocampal lesions were shown to be PAS positive, H and E negative, and immunoreactive for tau protein and alpha synuclein, but not to Abeta 1-40 or Abeta 1-42, or for ubiquitin. These were quantitated by histomorphometry, and QTL analysis revealed a locus on chromosome 7 with a lod score of 6.5 as well as two suggestive loci on chromosome 10. The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus. PUBMED: 12828934
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