GeneSet Information

Tier II GS135887 • fasting plasma insulin (Fpli, Published QTL Chr 3)

DESCRIPTION:

QTL associated with fasting plasma insulin. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (143417717)

LABEL:

QTL-Fpli-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2660570

AUTHORS:

Suto J, Sekikawa K

TITLE:

A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-A(y) mice.

JOURNAL:

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Nov 2002, Vol 26, pp. 1517-9

ABSTRACT:

KK and KK-A(y) mice serve as animal models of non-insulin-dependent diabetes mellitus with moderate obesity. Quantitative trait locus (QTL) analysis was performed to identify gene loci that account for fasting hyperglycemia, glucose intolerance and plasma insulin in 91 F(2) females of a C57BL/6JxKK-A(y) intercross. For glucose intolerance, a significant QTL was identified on chromosome 8, with a maximum lod score of 5.6. This locus had strong influence on the late phase of the intraperitoneal glucose tolerance test (IPGTT), suggesting that the locus may have role in glucose clearance rather than in mere hyperglycemia. In addition, three suggestive QTLs were identified on chromosomes 1 (fasting glucose), 3 (fasting insulin) and 4, (blood glucose at 120 min during IPGTT, and glucose intolerance). PUBMED: 12439655
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Annotation Information

No sequence read archive data associated with this GeneSet.


Chromosomes, Human, Pair 8 (D002898)
Animals (D000818)
Glucose (D005947)
Diabetes Mellitus, Type 2 (D003924)
Diabetes Mellitus (D003920)
Fasting (D005215)
Mice (D051379)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Glucose Intolerance (D018149)
Models, Animal (D023421)
Role (D012380)
Insulin (D007328)
Plasma (D010949)
Glucose Tolerance Test (D005951)
Obesity (D009765)
Lod Score (D008126)
Hyperglycemia (D006943)
Maps (D019532)
plasma (MA:0002501)
obese (MP:0001261)
hyperglycemia (MP:0001559)
impaired glucose tolerance (MP:0005293)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351