GeneSet Information

Tier II GS135857 • femoral bone morphometry 7 (Fembm7, Published QTL Chr 19)

DESCRIPTION:

QTL associated with femoral bone morphometry 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (47227275)

LABEL:

QTL-Fembm7-Mouse-Chr 19

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Drake TA, Hannani K, Kabo JM, Villa V, Krass K, Lusis AJ

TITLE:

Genetic loci influencing natural variations in femoral bone morphometry in mice.

JOURNAL:

Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jul 2001, Vol 19, pp. 511-7

ABSTRACT:

This study identifies genetic loci affecting femoral bone length and width measures in mature mice. Sixteen month old female F2 progeny of a C57BL/6J and DBA/2J intercross were examined for femur length and width of the femoral head, intertrochanteric region and three locations of the diaphysis using digitized images of femur radiographs obtained in the anterior-posterior and lateral projections. A genome wide linkage map was constructed using microsatellite markers at an average density of 20 cM, and quantitative trait locus analysis used to identify regions of the genome showing linkage with the traits measured. Femur length showed significant linkage with loci on proximal chromosome 3 (lod 6.1), and suggestive linkage with a locus on chromosome 14. A major locus on mid-chromosome 7 controlled width of the diaphysis (lod 6.8). Other loci were identified on chromosomes 2 and 4. Width at the intertrochanteric region had suggestive linkage with loci on chromosomes 6 and 19. No loci were found with linkage for width of the femoral head. Candidate genes related to bone development or metabolism are present at most of these loci. These findings show that genetic regulation of femoral bone morphology is complex, and are consistent with the distinct biologic processes that control longitudinal and lateral growth of the femur. PUBMED: 11518254
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Annotation Information



Social Control, Formal (D012926)
Chromosomes, Human, Pair 3 (D002893)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Microsatellite Repeats (D018895)
Chromosomes, Human, Pair 14 (D002883)
Genetic Loci (D056426)
Bone Development (D001846)
Bone and Bones (D001842)
Metabolism (D008660)
Diaphyses (D018483)
bone development (GO:0060348)
metabolic process (GO:0008152)
chromosome (GO:0005694)

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