DESCRIPTION:

QTL associated with experimental severe malaria resistance. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (56130259)

LABEL:

QTL-Esmr-Mouse-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-10-22

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2181163

AUTHORS:

Nagayasu E, Nagakura K, Akaki M, Tamiya G, Makino S, Nakano Y, Kimura M, Aikawa M

TITLE:

Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria.

JOURNAL:

Infection and immunity Feb 2002, Vol 70, pp. 512-6

ABSTRACT:

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F(2) intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM. PUBMED: 11796577
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