GeneSet Information

Tier II GS135763 • experimental allergic encephalomyelitis susceptibility 5 (Eae5, Published QTL Chr 17)


QTL associated with experimental allergic encephalomyelitis susceptibility 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (41438808)


QTL-Eae5-Mouse-Chr 17









Teuscher C, Doerge RW, Fillmore PD, Blankenhorn EP


eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter.


Genetics Feb 2006, Vol 172, pp. 1147-53


Genetic factors are believed to contribute to multiple sclerosis (MS) susceptibility; however, strong evidence implicating intrinsic and environmental factors in the etiopathogenesis of MS also exists. Susceptibility to experimental allergic encephalomyelitis (EAE), the principal animal model of MS, is also influenced by nongenetic factors, including age and season at immunization. This suggests that age- and season-by-gene interactions exist and that different susceptibility loci may influence disease as a function of the two parameters. In this study, linkage analysis based on genome exclusion mapping was carried out using age and season at immunization restricted cohorts of (B10.S x SJL/J) F2 intercross mice in an effort to identify such linkages. Significant linkage of EAE to eae4 and eae5 was detected with 6- to 12-week-old and summer cohorts. In contrast, significant linkage of EAE to eae4 and eae5 was not detected with the >12-week-old and winter/spring populations. Rather, significant linkage to D4Mit203 at 128.50 Mb on chromosome 4 was detected with animals that were >12 weeks old at the time of immunization or were immunized in the winter. This previously unidentified locus has been designated eae36. These results support the existence of age- and season-by-gene-specific interactions in the genetic control of susceptibility to autoimmune inflammatory disease of the central nervous system and suggest that late-onset MS may be immunogenetically distinct. PUBMED: 16299394
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Annotation Information

Chromosomes, Human, Pair 4 (D002894)
Animals (D000818)
Chromosomes (D002875)
Seasons (D012621)
Models, Animal (D023421)
Central Nervous System (D002490)
Multiple Sclerosis (D009103)
Sclerosis (D012598)
Nervous System (D009420)
Encephalomyelitis (D004679)
Encephalomyelitis, Autoimmune, Experimental (D004681)
Immunization (D007114)
central nervous system (MA:0000167)
nervous system (MA:0000016)
CNS inflammation (MP:0006082)
chromosome (GO:0005694)

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