DESCRIPTION:

QTL associated with compensatory renal hypertrophy QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (98544969)

LABEL:

QTL-Crhq1-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1298385

AUTHORS:

Zdek V, Musilov A, Vorlek J, Simkov M, Pravenec M

TITLE:

Quantitative trait loci for compensatory renal hypertrophy in the mouse.

JOURNAL:

Biochemical and biophysical research communications Jul 1998, Vol 248, pp. 473-5

ABSTRACT:

Reduction in numbers of nephrons or decrease in kidney function due to a variety of diseases results in compensatory renal hypertrophy (CRH). Recently, it has been proposed that CRH may be a prerequisite for progression of renal injury; genetic dissection of CRH may be therefore helpful in understanding the process whereby people with partial renal insufficiency progress to end-stage renal disease. Since genetic analysis of CRH in humans is quite limited, we searched for genetic determinants of CRH after unilateral nephrectomy using a total genome scan of the mouse BXD recombinant inbred strains. We demonstrated that CRH is a highly heritable trait and we identified a quantitative trait locus on mouse chromosome 11 near the D11Mit14 marker that exerts a major effect on CRH (lod score = 3.4) and is responsible for approximately 52% of genetic variation in CRH. This marker maps near Ace, Gh, and Ngfr positional candidate genes. PUBMED: 9703949
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