DESCRIPTION:

QTL associated with circadian photosensitivity 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (12172308)

LABEL:

QTL-Circp2-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2661439

AUTHORS:

Yoshimura T, Yokota Y, Ishikawa A, Yasuo S, Hayashi N, Suzuki T, Okabayashi N, Namikawa T, Ebihara S

TITLE:

Mapping quantitative trait loci affecting circadian photosensitivity in retinally degenerate mice.

JOURNAL:

Journal of biological rhythms Dec 2002, Vol 17, pp. 512-9

ABSTRACT:

It is known that retinally degenerate C57BL/6J (rd/rd) mice have unattenuated circadian photosensitivity. However, the authors have previously found that CBA/J (rd/rd) mice that carry the same rd mutation have attenuated circadian photosensitivity compared to normal CBA/N (+/+) mice. In the present study, a quantitative trait locus (QTL) analysis using C57BL/6J (rd/rd) and CBA/J (rd/rd) mice was conducted in order to identify the genes affecting circadian photosensitivity of the rd mice. As a result, several putative QTLs onthree separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes. Identification of these genes may provide new insights into the understanding of regulation of circadian photoentrainment and sleep-wake disorders. PUBMED: 12465884
Find other GeneSets from this publication