GeneSet Information

Tier II GS135634 • collagen induced arthritis QTL 6 (Cia6, Published QTL Chr 6)

DESCRIPTION:

QTL associated with collagen induced arthritis QTL 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (75397577)

LABEL:

QTL-Cia6-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1345671

AUTHORS:

Ibrahim SM, Koczan D, Thiesen HJ

TITLE:

Gene-expression profile of collagen-induced arthritis.

JOURNAL:

Journal of autoimmunity Mar 2002, Vol 18, pp. 159-67

ABSTRACT:

To provide a global analysis of genes involved in the inflammatory process in joints of DBA/1J mice suffering from collagen induced arthritis (CIA) we used oligonucleotide microarrays representing approximately 11,000 genes to determine the gene expression profile of the inflamed paws at peak of disease, and compared them to normal tissue. Peak of disease was determined from clinical evaluation of disease and histopathology of joints. Of the 11,000 genes assayed, 223 showed differential expression of four fold or more (187 upregulated and 36 downregulated). Ninety-five of the genes observed had well-characterized full length sequences in databases, and 128 were unknown (Ests). Inflammation resulted in a profile of increased gene expression of matrix metalloproteinases, immune-related, extra-cellular matrix and cell adhesion molecules, as well as molecules involved in cell division and transcription; differential regulation of molecules involved in signal transduction, protein synthesis and metabolism. Of the 55 genes with known chromosomal locations nine mapped to previously identified QTL, contributing to susceptibility or severity of CIA, i.e. MHC class I, II, Basigin, FAP, Cathepsin K, CD 53, RAF1, glucagon, and retinal taurine transporter. The profile of gene expression supports current theoretical models of disease progression and might open new perspectives for both diagnosis and treatment of arthritis. PUBMED: 11908948
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Annotation Information

No sequence read archive data associated with this GeneSet.


Social Control, Formal (D012926)
Joints (D007596)
Cell Adhesion Molecules (D015815)
Major Histocompatibility Complex (D008285)
Taurine (D013654)
Cathepsin K (D056657)
Mice (D051379)
Gene Expression Profiling (D020869)
Antigens, CD147 (D051926)
Cell Adhesion (D002448)
Matrix Metalloproteinases (D020782)
Therapeutics (D013812)
Evaluation Studies as Topic (D005069)
Classification (D002965)
Models, Theoretical (D008962)
Tissues (D014024)
Oligonucleotide Array Sequence Analysis (D020411)
Inflammation (D007249)
Cells (D002477)
Diagnosis (D003933)
Collagen (D003094)
Stress, Psychological (D013315)
Cathepsins (D002403)
Disease Progression (D018450)
Retinaldehyde (D012172)
Arthritis, Experimental (D001169)
Arthritis (D001168)
Signal Transduction (D015398)
Metalloproteases (D045726)
Cell Division (D002455)
Metabolism (D008660)
Glucagon (D005934)
arthritis (MP:0002993)
abnormal inflammatory response (MP:0001845)
cell adhesion (GO:0007155)
metabolic process (GO:0008152)
cell (GO:0005623)
biosynthetic process (GO:0009058)
transduction (GO:0009293)
collagen (GO:0005581)
signal transduction (GO:0007165)
gene expression (GO:0010467)
cell division (GO:0051301)
translation (GO:0006412)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351