GeneSet Information

Tier II GS135609 • circulating hormone level QTL 18 (Chlq18, Published QTL Chr 7)


QTL associated with circulating hormone level QTL 18. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (65754442)


QTL-Chlq18-Mouse-Chr 7









Hanlon P, Lorenz WA, Shao Z, Harper JM, Galecki AT, Miller RA, Burke DT


Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I.


Physiological genomics Jun 2006, Vol 26, pp. 46-54


A previous analysis of serum insulin-like growth factor I (IGF-I) levels in a mouse population (n = 961) derived from a cross of (BALB/cJ x C57BL/6J) F1 females and (C3H/HeJ x DBA/2J) F1 males documented quantitative trait loci (QTL) on chromosomes 1, 10, and 17. We employed a newly developed, random walk-based method to search for three- and four-way allelic combinations that might influence IGF-I levels through nonadditive (conditional or epistatic) interactions among 185 genotyped biallelic loci and with significance defined by experiment-wide permutation (P < 0.05). We documented a three-locus combination in which an epistatic interaction between QTL on paternal-derived chromosomes 5 and 18 had an opposite effect on the phenotype based on the allele inherited at a third locus on maternal-derived chromosome 17. The search also revealed three four-locus combinations that influence IGF-I levels through nonadditive genetic interactions. In two cases, the four-allele combinations were associated with animals having high levels of IGF-I, and, in the third case, a four-allele combination was associated with animals having low IGF-I levels. The multiple-locus genome scan algorithm revealed new IGF-I QTL on chromosomes 2, 4, 5, 7, 8, and 12 that had not been detected in the single-locus genome search and showed that levels of this hormone can be regulated by complex, nonadditive interactions among multiple loci. The analysis method can detect multilocus interactions in a genome scan experiment and may provide new ways to explore the genetic architecture of complex physiological phenotypes. PUBMED: 16782841
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Annotation Information

Alleles (D000483)
Animals (D000818)
Insulin-Like Growth Factor I (D007334)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Fibrinogen (D005340)
Chromosomes, Human, Pair 17 (D002886)
Architecture as Topic (D001108)
Hormones (D006728)
Algorithms (D000465)
chromosome (GO:0005694)

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