GeneSet Information

Tier II GS135594 • mean cell hemoglobin concentration QTL 1 (Chcmq1, Published QTL Chr 2)

DESCRIPTION:

QTL associated with mean cell hemoglobin concentration QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (101018300)

LABEL:

QTL-Chcmq1-Mouse-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Peters LL, Lambert AJ, Zhang W, Churchill GA, Brugnara C, Platt OS

TITLE:

Quantitative trait loci for baseline erythroid traits.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Apr 2006, Vol 17, pp. 298-309

ABSTRACT:

A substantial genetic contribution underlies variation in baseline peripheral blood counts. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline erythroid parameters in F2 intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice. We identified multiple significant QTL for red blood cell (RBC) count, hemoglobin (Hgb) and hematocrit (Hct) levels, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean cell hemoglobin concentration (CHCM). We identified four RBC count QTL: Rbcq1 (Chr 1, peak LOD score at 62 cM,), Rbcq2 (Chr 4, 60 cM), Rbcq3 (Chr 11, 34 cM), and Rbcq4 (Chr 10, 60 cM). Three MCV QTL were identified: Mcvq1 (Chr 7, 30 cM), Mvcq2 (Chr 11, 6 cM), and Mcvq3 (Chr 10, 60 cM). Single significant loci for Hgb (Hgbq1, Chr 16, 32 cM), Hct (Hctq1, Chr 3, 42 cM), and MCH (Mchq1, Chr 10, 60 cM) were identified. The data support the existence of a common RBC/MCH/MCV locus on Chr 10. Two QTL for CHCM (Chcmq1, Chr 2, 48 cM; Chcmq2, Chr 9, 44 cM) and an interaction between Chcmq2 with a locus on Chr 19 were identified. These analyses emphasize the genetic complexity underlying the regulation of erythroid peripheral blood traits in normal populations and suggest that genes not previously recognized as significantly impacting normal erythropoiesis exist. PUBMED: 16596451
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Annotation Information



Social Control, Formal (D012926)
Erythropoiesis (D004920)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Blood Cells (D001773)
Hematocrit (D006400)
Attention (D001288)
Erythrocyte Indices (D004909)
Hemoglobins (D006454)
Erythrocytes (D004912)
Lod Score (D008126)
abnormal mean corpuscular hemoglobin (MP:0001589)
erythrocyte differentiation (GO:0030218)
chromosome (GO:0005694)

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