DESCRIPTION:

QTL associated with cystic fibrosis survival to weaning 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (107842159)

LABEL:

QTL-Cfsw2-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2670600

AUTHORS:

Haston CK, Tsui LC

TITLE:

Loci of intestinal distress in cystic fibrosis knockout mice.

JOURNAL:

Physiological genomics Jan 2003, Vol 12, pp. 79-84

ABSTRACT:

The strain-dependent survival of cystic fibrosis (CF) knockout mice has been used to map a modifier of CF, Cfm1, in mice and, subsequently, in humans. To identify additional modifiers of the CF phenotype, in this study, the survival of F2 CF mice derived from a cross between congenic C57BL/6J CF and BALB/cJ CF heterozygotes was followed up to 12 wk of age. A genome-wide linkage scan completed in F2 CF mice revealed a chromosome 10 locus (P = 1.2 x 10(-4)) to predict for intestinal distress in CF male mice. An X chromosome locus for which non-Mendelian inheritance favoring B6 alleles in the surviving CF mice and BALB alleles in mice of a control population, was identified. The survival of female mice, both F2 CF and F2 control, was linked to loci on chromosomes 3 and 5. The identification of additional putative CF modifier loci may permit further genetic dissection of the complex CF phenotype. PUBMED: 12441405
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