GeneSet Information

Tier II GS135540 • cerebellum weight 2 (Cbm2, Published QTL Chr 8)


QTL associated with cerebellum weight 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (98042513)


QTL-Cbm2-Mouse-Chr 8









Airey DC, Lu L, Williams RW


Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture.


The Journal of neuroscience : the official journal of the Society for Neuroscience Jul 2001, Vol 21, pp. 5099-109


To discover genes influencing cerebellum development, we conducted a complex trait analysis of variation in the size of the adult mouse cerebellum. We analyzed two sets of recombinant inbred BXD strains and an F2 intercross of the common inbred strains, C57BL/6J and DBA/2J. We measured cerebellar size as the weight or volume of fixed or histologically processed tissue. Among BXD recombinant inbred strains, the cerebellum averages 52 mg (12.4% of the brain) and ranges 18 mg in size. In F2 mice, the cerebellum averages 62 mg (12.9% of the brain) and ranges approximately 20 mg in size. Five quantitative trait loci (QTLs) that significantly control variation in cerebellar size were mapped to chromosomes 1 (Cbs1a), 8 (Cbs8a), 14 (Cbs14a), and 19 (Cbs19a, Cbs19b). In combination, these QTLs can shift cerebellar size an appreciable 35% of the observed range. To assess regional genetic control of the cerebellum, we also measured the volume of the cell-rich, internal granule layer (IGL) in a set of BXD strains. The IGL ranges from 34 to 43% of total cerebellar volume. The QTL Cbs8a is significantly linked to variation in IGL volume and is suggestively linked to variation in the number of cerebellar folia. The QTLs we have discovered are among the first loci shown to modulate the size and architecture of the adult mouse cerebellum. PUBMED: 11438585
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Annotation Information

Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Tissues (D014024)
Architecture as Topic (D001108)
Cerebellum (D002531)
Identification (Psychology) (D007062)
Set (Psychology) (D012718)
cerebellum (MA:0000198)
cerebellum development (GO:0021549)

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