GeneSet Information

Tier II GS135529 • castaneus 10 week body weight 4 (C10bw4, Published QTL Chr 13)

DESCRIPTION:

QTL associated with castaneus 10 week body weight 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (72374309)

LABEL:

QTL-C10bw4-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Ishikawa A, Matsuda Y, Namikawa T

TITLE:

Detection of quantitative trait loci for body weight at 10 weeks from Philippine wild mice.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Oct 2000, Vol 11, pp. 824-30

ABSTRACT:

A genome-wide scan for quantitative trait loci (QTLs) controlling body weight at 10 weeks after birth was carried out in a population of 387 intersubspecific backcross mice derived from a cross between C57BL/6J inbred mice (Mus musculus domesticus) and wild mice (M. m. castaneus) captured in the Philippines, in order to discover novel QTLs from the wild mice that have about 60% lower body weight than C57BL/6J. By interval mapping, we detected four QTLs: a highly significant QTL on Chromosome (Chr) 2, which was common in both sexes; two significant QTLs on Chr 13, one male-specific and the other female-specific; and a suggestive male-specific QTL on X Chr. By composite interval mapping, we confirmed the presence of the three QTLs on Chrs 2 and 13, but not of the male-specific X-linked QTL. The composite interval mapping analysis newly identified three QTLs: a significant male-specific QTL on Chr 11 and two highly significant female-specific QTLs on Chrs 9 and X. Individual QTLs explained 3.8-11.6% of the phenotypic variance, and all the QTL alleles derived from the wild mice decreased body weight. A two-way analysis of variance revealed a significant epistatic interaction between the Chr 2 QTL and the background marker locus D12Mit4 on Chr 12 only in males. The interaction effect unexpectedly increased body weight. The chromosomal region containing the Chr 2 QTL did not coincide with those of growth or fatness QTLs mapped in previous studies. These results suggest that a population of wild mice may play an important role as new sources of valuable QTLs. PUBMED: 11003694
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Annotation Information



Alleles (D000483)
Play and Playthings (D010988)
Philippines (D010679)
Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Dihydrotachysterol (D004097)
Zellweger Syndrome (D015211)
Body Weight (D001835)
Parturition (D036801)
Analysis of Variance (D000704)
increased body weight (MP:0001260)
decreased body weight (MP:0001262)
chromosome (GO:0005694)

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