GeneSet Information

Tier II GS135507 • body weight QTL 4 (Bw4, Published QTL Chr 11)


QTL associated with body weight QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (83403911)


QTL-Bw4-Mouse-Chr 11









Aksu S, Koczan D, Renne U, Thiesen HJ, Brockmann GA


Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines.


Journal of applied genetics None 2007, Vol 48, pp. 133-43


Recently, quantitative trait loci (QTLs) for body weight and obesity have been mapped in an intercross population between the high body weight-selected mouse line DU6i and the inbred line DBA/2. Most QTLs were highly significant, but had small effects only. Under the hypothesis that small-effect QTLs might result from changes in gene activity, our strategy to identify candidate genes for the observed effects was directed towards the identification of differentially expressed genes. Therefore, here we compare the transcription profile of about 11 000 genes in epididymal fat tissues of males of two high body weight-selected (DU6 and DU6i) and two unselected mouse lines (DUKs and DBA/2). For the hybridisation of GeneChips, we used pooled samples of 20 individual mice. By pair-wise comparisons between selected and unselected mouse lines, a set of 77 genes was identified representing genes whose level of expression differed between obese and lean mouse strains. According to the functional classification of genes, 69 differentially expressed genes were involved in regulatory and metabolic pathways, cell division, cell stability, or immune response, and thus might have an effect on body weight and fat accumulation. 14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes. PUBMED: 17495347
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Annotation Information

Quantitative Trait Loci (D040641)
Abdominal Fat (D050153)
Classification (D002965)
Tissues (D014024)
Obesity (D009765)
Identification (Psychology) (D007062)
Metabolic Networks and Pathways (D053858)
Body Weight (D001835)
Set (Psychology) (D012718)
Cell Division (D002455)
adipose tissue (MA:0000009)
immune response (GO:0006955)
cell division (GO:0051301)

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