DESCRIPTION:

QTL associated with bladder tumor susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (29701222)

LABEL:

QTL-Bts2-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1934674

AUTHORS:

Higashi S, Murai T, Mori S, Kamoto T, Yoshitomi M, Arakawa Y, Makino S, Fukushima S, Yoshida O, Hiai H

TITLE:

Host genes affecting survival period of chemically induced bladder cancer in mice.

JOURNAL:

Journal of cancer research and clinical oncology None 1998, Vol 124, pp. 670-6

ABSTRACT:

Treatment of C57BL/6 J (B6) and NON male mice with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) resulted in a high incidence of bladder cancer. The mean survival period, however, differed significantly by strain: 481+/-219 days in B6 (n = 31) and 203+/-119 days in NON (n = 30) (P < 0.0001). Major causes of death were renal failure due to obstruction of the urinary tract, or local invasion of tumors. The fact that the BBN-treated NON x B6 reciprocal F1 mice had survival periods as short as those of the parental NON mice suggests a genetically dominant susceptibility in NON or recessive resistance in B6. A linkage analysis of 248 back-cross mice to B6 suggested at least two quantitative trait loci determining the length of the survival period: one was mapped close to D2Mit260 (logarithm of odds, LOD, score 2.21), a microsatellite marker locus 83 cM from the centromere on chromosome 2, and another was close to D6Mit159, 7 cM from the centromere on chromosome 6 (LOD score 2.51). PUBMED: 9879827
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