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Tier II GS135416 • beta-carboline-induced seizures 1 (Bis1, Published QTL Chr 4)

DESCRIPTION:

QTL associated with beta-carboline-induced seizures 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (136693037)

LABEL:

QTL-Bis1-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:104794

AUTHORS:

Zerr P, Martin B, Adelman JP

TITLE:

The murine Bis1 seizure gene and the Kcnab2 gene encoding the beta2-subunit of the K+ channel are different.

JOURNAL:

Neurogenetics Mar 2000, Vol 2, pp. 231-4

ABSTRACT:

We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the beta2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed. PUBMED: 10983719
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Annotation Information

No sequence read archive data associated with this GeneSet.

Social Control, Formal (D012926)

Chromosomes, Human, Pair 4 (D002894)

Clinical Coding (D059019)

Seizures (D012640)

DNA (D004247)

Mice (D051379)

Chromosomes (D002875)

Affect (D000339)

Sequence Analysis (D017421)

Sequence Analysis, DNA (D017422)

Genes, vif (D016341)

Base Sequence (D001483)

Confidence Intervals (D016001)

seizures (MP:0002064)

chromosome (GO:0005694)

QTL map (EDAM_data:1860)

Gene List • 743 Genes

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GeneSet Information

Tier II GS135416 • beta-carboline-induced seizures 1 (Bis1, Published QTL Chr 4)

Annotation Information

Gene List • 743 Genes

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GeneSet Information

Tier II GS135416 • beta-carboline-induced seizures 1 (Bis1, Published QTL Chr 4)

Annotation Information

Gene List • 743 Genes

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