DESCRIPTION:

QTL associated with bronchial hyperresponsiveness 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37927844)

LABEL:

QTL-Bhr6-Mouse-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2150651

AUTHORS:

De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM

TITLE:

Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.

JOURNAL:

The American journal of physiology Dec 1999, Vol 277, pp. L1118-23

ABSTRACT:

Quantitative trait locus (QTL) mapping was used to identify chromosomal regions contributing to airway hyperresponsiveness in mice. Airway responsiveness to methacholine was measured in A/J and C3H/HeJ parental strains as well as in progeny derived from crosses between these strains. QTL mapping of backcross [(A/J x C3H/HeJ) x C3H/HeJ] progeny (n = 137-227 informative mice for markers tested) revealed two significant linkages to loci on chromosomes 6 and 7. The QTL on chromosome 6 confirms the previous report by others of a linkage in this region in the same genetic backgrounds; the second QTL, on chromosome 7, represents a novel locus. In addition, we obtained suggestive evidence for linkage (logarithm of odds ratio = 1.7) on chromosome 17, which lies in the same region previously identified in a cross between A/J and C57BL/6J mice. Airway responsiveness in a cross between A/J and C3H/HeJ mice is under the control of at least two major genetic loci, with evidence for a third locus that has been previously implicated in an A/J and C57BL/6J cross; this indicates that multiple genetic factors control the expression of this phenotype. PUBMED: 10600881
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