DESCRIPTION:

QTL associated with body growth early QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (117993078)

LABEL:

QTL-Bgeq10-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:108505

AUTHORS:

Cheverud JM, Routman EJ, Duarte FA, van Swinderen B, Cothran K, Perel C

TITLE:

Quantitative trait loci for murine growth.

JOURNAL:

Genetics Apr 1996, Vol 142, pp. 1305-19

ABSTRACT:

Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice. Weekly weights (1-10 wk) and 75 microsatellite genotypes were obtained for 535 mice. Interval mapping was used to locate and measure the genotypic effects of QTLs on body weight and growth. QTL effects were detected on 16 of the 19 autosomes with several chromosomes carrying more than one QTL. The number of QTLs for age-specific weights varied from seven at 1 week to 17 at 10 wk. The QTLs were each of relatively minor, subequal effect. QTLs affecting early and late growth were generally distinct, mapping to different chromosomal locations indicating separate genetic and physiological systems for early and later murine growth. PUBMED: 8846907
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