DESCRIPTION:

QTL associated with body weight 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (19721387)

LABEL:

QTL-Bdw1-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3589618

AUTHORS:

Kim EH, Lee CH, Hyun BH, Suh JG, Oh YS, Namikawa T, Ishikawa A

TITLE:

Quantitative trait Loci for glomerulosclerosis, kidney weight and body weight in the focal glomerulosclerosis mouse model.

JOURNAL:

Experimental animals / Japanese Association for Laboratory Animal Science Jul 2005, Vol 54, pp. 319-25

ABSTRACT:

In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance. PUBMED: 16093645
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