GeneSet Information

Tier II GS135330 • autoimmune renal vasculitis 2 (Arvm2, Published QTL Chr 4)

DESCRIPTION:

QTL associated with autoimmune renal vasculitis 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (124575015)

LABEL:

QTL-Arvm2-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Qu WM, Miyazaki T, Terada M, Lu LM, Nishihara M, Yamada A, Mori S, Nakamura Y, Ogasawara H, Yazawa C, Nakatsuru S, Nose M

TITLE:

Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c allele.

JOURNAL:

European journal of immunology Jul 2000, Vol 30, pp. 2027-37

ABSTRACT:

An MRL/MpJ strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), composed of genomes derived from LG/J, AKR/J, C3H/Di and C57BL/6J mice, develops systemic vasculitis coincidentally with other collagen diseases, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. In a genome-wide screening of the MRL background genes mediating susceptibility to collagen diseases using N2 progeny mice MRL/lpr x (MRL/lpr x C3H/lpr)F1, we previously found that each collagen disease is controlled by a different set of genes. To clarify the candidate genes for vasculitis, we extended the linkage analysis of renal vasculitis to a larger number of N2 mice and to F2 intercross mice. Two distinct recessive susceptibility loci for vasculitis were mapped on chromosome (Chr) 4 at D4Mit89 and D4Mit147 in both progenies. The former was a novel locus for lupus phenotypes, which involved the MRL allele CD72(c) in contrast to the C3H allele CD72(b). The one on Chr 3 was a recessive locus which had an inhibitory effect on vasculitis. From their composition these loci seemed to be derived from AKR/J (for one) and LG/J (for another two) strains, and appeared to act in an additive manner on the development of vasculitis, indicating that vasculitis in MRL/lpr mice is inherited in a polygenic manner. PUBMED: 10940892
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Annotation Information



Alleles (D000483)
Negotiating (D017008)
Chromosomes (D002875)
Dissection (D004210)
Vasculitis (D014657)
Mass Screening (D008403)
Collagen Diseases (D003095)
Collagen (D003094)
Systemic Vasculitis (D056647)
Set (Psychology) (D012718)
vasculitis (MP:0001864)
chromosome (GO:0005694)

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