DESCRIPTION:

QTL associated with angiogenesis due to FGF2 QTL 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (77065228)

LABEL:

QTL-Angfq4-Mouse-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3046558

AUTHORS:

Rogers MS, Rohan RM, Birsner AE, D\'Amato RJ

TITLE:

Genetic loci that control the angiogenic response to basic fibroblast growth factor.

JOURNAL:

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul 2004, Vol 18, pp. 1050-9

ABSTRACT:

Angiogenesis is controlled by a balance between stimulatory growth factors and endogenous inhibitors. We propose that the balance of stimulators and inhibitors, as well as the general sensitivity of the endothelium to these factors, varies from individual to individual. Indeed, we have found that individual mouse strains have dramatically different responses to growth factor-induced neovascularization. Quantitative trait loci (QTLs), which influence the extent of angiogenesis induced by vascular endothelial growth factor (VEGF), were previously identified by our laboratory. Since genetic susceptibility may vary according to the angiogenic stimulator, we have undertaken a similar mapping approach to identify QTLs that influence basic fibroblast growth factor (FGF2) induced neovascularization in the BXD series of recombinant inbred mouse strains. Composite and multiple interval mapping identified areas of chromosomes 4, 13, 15, and 18. These new angiogenesis QTLs, named AngFq1 through AngFq4 (for angiogenesis due to FGF2), are different from previously identified VEGF QTLs. The mapped regions contain several genes involved in the angiogenic process including matrix metalloproteinase 16, eph receptor A7, angiopoetin 1, endothelial lipase, and autotaxin. Differences in these regions may influence individual susceptibility to angiogenesis related diseases such as cancer, macular degeneration, atherosclerosis, and arthritis. PUBMED: 15226265
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