GeneSet Information

Tier II GS135296 • acute lung injury QTL 3 (Aliq3, Published QTL Chr 17)


QTL associated with acute lung injury QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (80977459)


QTL-Aliq3-Mouse-Chr 17









Cho HY, Kleeberger SR


Genetic mechanisms of susceptibility to oxidative lung injury in mice.


Free radical biology & medicine Feb 2007, Vol 42, pp. 433-45


Genetic background is a known predisposing risk factor for many acute and chronic pulmonary disorders and responses to environmental oxidants. Variation in lung injury responses to oxidative stimuli such as ozone, particles, hyperoxia, and chemotherapeutic agents between genetically standardized inbred mouse strains has been demonstrated. In this review, we discuss quantitative trait loci (QTLs) which contain candidate genes that confer differential susceptibility to oxidative stimuli between strains in mouse models of airway toxicity and disease. We addressed multiple inflammatory, immunity, and antioxidant genes identified as candidate genetic determinants following these strategies, which include tumor necrosis factor (Tnf), toll-like receptor 4 (Tlr4), and the transcription factor NF-E2, related factor 2 (Nrf2). Mice with targeted deletion of these and related genes have provided initial proof of concept for their importance in the respective models. Interestingly, a few regions of the genome appear to have important roles in determining susceptibility to a number of stimuli which may suggest common genetic mechanisms in mice. Though more complete examination of functional association is required, results have potential implications for the role of these candidate genes in the pathogenesis of human pulmonary diseases including asthma, acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and emphysema. PUBMED: 17275675
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Annotation Information

Fibrosis (D005355)
Lung Diseases (D008171)
Tumor Necrosis Factor-alpha (D014409)
Immunity (D007109)
Emphysema (D004646)
Quantitative Trait Loci (D040641)
Hyperoxia (D018496)
Acute Lung Injury (D055371)
Lung Injury (D055370)
Neoplasms (D009369)
Wounds and Injuries (D014947)
Oxidants (D016877)
Risk Factors (D012307)
Pulmonary Fibrosis (D011658)
Mice, Inbred Strains (D008815)
Transcription Factors (D014157)
Respiratory Distress Syndrome, Adult (D012128)
Idiopathic Pulmonary Fibrosis (D054990)
Association (D001244)
Necrosis (D009336)
Toll-Like Receptors (D051193)
Toll-Like Receptor 4 (D051197)
hyperoxia (MP:0002319)
emphysema (MP:0001958)
respiratory distress (MP:0001954)
pulmonary fibrosis (MP:0006050)
pathogenesis (GO:0009405)

Gene List • 231 Genes

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