DESCRIPTION:

QTL associated with "alcohol preference locus 2, female specific". This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (72132472)

LABEL:

QTL-Alcp2-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:107452

AUTHORS:

Foroud T, Li TK

TITLE:

Genetics of alcoholism: a review of recent studies in human and animal models.

JOURNAL:

The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions Fall 1999, Vol 8, pp. 261-78

ABSTRACT:

There is substantial evidence for a significant genetic component to the risk of alcoholism. In searching for genes that contribute to this risk, several approaches may be utilized in order to identify the genetic loci underlying alcoholism susceptibility. Several candidate genes have been evaluated for their role in alcoholism; however, with the exception of the enzymes of alcohol metabolism, results from these studies have been inconsistent. Recently, two large studies have employed a genome screen methodology to identify novel genes contributing to the risk of alcoholism. As an alternative strategy, researchers have utilized mouse and rat models to identify quantitative trait loci influencing alcohol preference. Through the development of congenic lines and transgenic and knock-out animals, candidate genes can be identified and evaluated for their role in alcohol preference. PUBMED: 10598210
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