GeneSet Information

Tier II GS135230 • activity-distance traveled 1 (Actd1, Published QTL Chr 1)


QTL associated with activity-distance traveled 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (103894727)


QTL-Actd1-Mouse-Chr 1









Koyner J, Demarest K, McCaughran J Jr, Cipp L, Hitzemann R


Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross.


Behavior genetics May 2000, Vol 30, pp. 159-70


A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombinant inbred series. QTLs were identified on chromosomes 1, 3, 5, 9, 10, 16, and 18. Some of these QTLs were detected across the entire experimental period (0-20 min), while others were associated with specific 5-min blocks. Eighteen hundred C57BL/6J (B6) x DBA/2J (D2) F2 intercross animals were phenotyped for the basal locomotor response, and of this group, 500 to 700 individuals, pseudo-randomly selected, were used for a genomewide scan to confirm the RI-generated QTLs and to detect new QTLs. No new QTLs were detected but the QTLs on chromosome 1 were confirmed at p < 10(-5) to p < 10(-9), depending on the time interval. In addition, the QTLs on chromosomes 5 and 9 were confirmed at p < 0.001, providing a combined probability (RI + F2) which exceeds the threshold for a significant association. Two additional phenotypes which showed significant RI strain differences were examined--adaptation and thigmotaxis. Adaptation mapped to the same region of chromosome 9 and thigmotaxis to the same region of chromosome 1 as the distance-traveled QTL. Overall, the data presented here and elsewhere (Flint et al., 1995; Gershenfeld et al., 1997) illustrate that QTLs for basal activity are both robust and reliable. PUBMED: 11105390
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Annotation Information

Chromosomes, Human, Pair 9 (D002899)
Animals (D000818)
Motor Activity (D009043)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Quantitative Trait Loci (D040641)
Overall (D016424)
Identification (Psychology) (D007062)
Probability (D011336)
Association (D001244)
thigmotaxis (GO:0001966)
chromosome (GO:0005694)

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