GeneSet Information

Tier II GS135229 • Angiostrongylus costaricensis nematode susceptibility 3 (Acsns3, Published QTL Chr 17)

DESCRIPTION:

QTL associated with Angiostrongylus costaricensis nematode susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34380179)

LABEL:

QTL-Acsns3-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2019-01-07

SPECIES:

AUTHORS:

Ohno T, Ishih A, Tanaka S, Nishimura M, Terada M

TITLE:

Chromosomal mapping of host susceptibility loci to Angiostrongylus costaricensis nematode infection in mice.

JOURNAL:

Immunogenetics Feb 2002, Vol 53, pp. 925-9

ABSTRACT:

Angiostrongylus costaricensis is a nematode found mainly as a rodent parasite. Laboratory mice were experimentally infected with this parasite. It is known that there is great variability in mortality among inbred mouse strains after infection with this nematode. The survival rate at 5 weeks after infection of A/J mice was 90.5%, whereas that of SM/J mice was only 33.3%, with severe anemia and decreased body weight about 3 weeks after infection. To identify host susceptibility genes for infection with this nematode, we undertook chromosomal mapping by a whole-genome scanning approach in (A/JxSM/J)F2 mice. We mapped a host susceptibility locus (here designated Acsns, for Angiostrongylus costaricensis nematode susceptibility locus) to the telomeric portion of Chromosome 19 (peak LOD=4.35). We also identified two loci on Chr 13 and Chr 17 that have epistatic effects on host survival. This is the first report on host susceptibility loci for helminth infection mapped by whole-genome scanning. PUBMED: 11862393
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Annotation Information



Laboratories (D007753)
Nematode Infections (D009349)
Survival Rate (D015996)
Chromosomes (D002875)
Research Report (D058028)
Helminths (D006376)
Parasites (D010271)
Chromosomes, Human, Pair 19 (D002888)
Angiostrongylus (D000801)
Mice, Inbred Strains (D008815)
Infection (D007239)
Survival (D013534)
Mortality (D009026)
Rodentia (D012377)
Body Weight (D001835)
decreased body weight (MP:0001262)
chromosome (GO:0005694)

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