DESCRIPTION:

Using literature search and bioinformatics tools, the present study characterizes the genes involved in alcohol induced liver injury. Pubmed search for the terms ‘alcohol, liver, genes’ yielded 1323 results. We selected 75 references involving almost 85 genes. Since a large number of studies in literature have documented alcohol me- diated liver injury, the study has been limited to certain specific alco- hol regulated genes which have been extensively studied in this context or have very profound implications on the occurrence of alco- hol induced liver injury. The human homologues of the genes expressed in the rodent an- imals were selected from the database of Human Gene Nomenclature Committee. Further, the ToppFun bioinformatics tool was used to study the various parameters. Sixteen diseases in which alcohol regu- lated hepatic genes were observed and all of them were significant. The database search yielded 1206 drugs which are metabolized by al- cohol responsive genes in liver, 586 drugs were significant and 83 drugs have been represented. A list of 569 metabolic processes cata- lyzed by alcohol responsive genes in liver was observed, of which 314 were significant and 50 metabolic processes are represented. Al- cohol regulated genes in liver were found to exhibit 48 molecular functions but 9 were insignificant. Alcohol regulated hepatic genes were found to metabolize 30 biological pathways, of which 21 were significant. Bonferroni's method was used to analyze the significance of the bioinformatics data and p < 0.05 was considered to be significant.

LABEL:

Alcohol/Drug-Liver Injury

SCORE TYPE:

P-Value

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Jagannathan L, Swaminathan K, Kumar SM, Kumar GR, Dey A

TITLE:

Bio-informatics based analysis of genes implicated in alcohol mediated liver injury.

JOURNAL:

Gene Feb 2012, Vol 494, pp. 130-9

ABSTRACT:

Alcohol induced liver injury has been studied extensively. Using literature search and bioinformatics tools, the present study characterizes the genes involved in alcohol induced liver injury. The cellular and metabolic processes in which genes involved in alcohol induced liver injury are implicated are also discussed. The genes related to alcohol induced liver injury are also involved in affecting certain molecular functions and metabolism of drugs, besides being associated with diseases. In conclusion, the changes in regulation of genes implicated in alcohol induced liver injury apart from causing alcohol mediated hepatic dysfunction may affect other vital processes in the body. PUBMED: 22155707
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