GeneSet Information

Tier II GS129190 • SGC/Knj cross B6 QTL 2 (Sxbq2 Published QTL Chr 6)

DESCRIPTION:

QTL associated with SGC/Knj cross B6 QTL 2. The confidence interval is Chr6:19862686-71272769 bp,+strand

LABEL:

QTL-Sxbq2-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K

TITLE:

Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice.

JOURNAL:

Journal of immunology (Baltimore, Md. : 1950) Mar 2006, Vol 176, pp. 3662-73

ABSTRACT:

The spontaneous crescentic glomerulonephritis-forming/Kinjoh (SCG/Kj) mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA). Although the disease is mediated initially by mutation of the Fas gene (lpr), SCG/Kj mice also have non-Fas predisposing genetic factors. To define these factors, genome-wide quantitative trait locus (QTL) mapping was performed on female (B(6)x SCG/Kj) F(2) intercross mice. Fourteen non-Fas QTLs were identified. QTLs of glomerulonephritis were located on chromosomes 1, 10, 13, 16, and 17, vasculitis on chromosomes 1 and 17, splenomegaly on chromosome 1, hypergammaglobulinemia on chromosomes 1, 2, 4, 6, 7, 11, 13, and 17, antinuclear Ab on chromosomes 1, 8, 10, and 12, and MPO-ANCA production on chromosomes 1 and 10. Significant QTLs derived from SCG/Kj on chromosomes 1, 2, 7, and 13 were designated Scg-1 to Scg-5, respectively, and those derived from B(6) on chromosomes 4, 6, 17, and 10 were designated Sxb-1 to Sxb-4, respectively. Two loci linked to MPO-ANCA production on chromosomes 1 and 10 were designated Man-1 and Man-2 (for MPO-ANCA), respectively. Although both Scg-1 and Scg-2 were on chromosome 1 and shared several functions, it was of interest that aberrant MPO-ANCA production was exclusively controlled by Man-1, the centromeric half region of the Scg-2 chromosomal segment. We also examined the epistatic effects between the lpr mutation and non-Fas susceptibility genes. QTLs are discussed in relation to previously described loci, with emphasis on their candidate genes. PUBMED: 16517735
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Annotation Information



Splenomegaly (D013163)
Chromosomes (D002875)
Chromosomes, Human, Pair 1 (D002878)
Quantitative Trait Loci (D040641)
Dissection (D004210)
Glomerulonephritis (D005921)
Vasculitis (D014657)
Peroxidase (D009195)
Hypergammaglobulinemia (D006942)
Mutation (D009154)
Confidence Intervals (D016001)
increased IgG level (MP:0002493)
glomerulonephritis (MP:0002743)
enlarged spleen (MP:0000691)
vasculitis (MP:0001864)
chromosome (GO:0005694)

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